Syntheses of 5'-amino-2',5'-dideoxy-2',2'-dif luorocytidine derivatives as novel anticancer nucleoside analogs

A novel class of 5'-amino-2',5'-dideoxy-2',2'-dif luorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to prov...

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Bibliographic Details
Published in:Tetrahedron letters 2014-01, Vol.55 (3), p.598-602
Main Authors: Labroli, Marc A, Dwyer, Michael P, Shen, Ruichao, Popovici-Muller, Janeta, Pu, Qinglin, Richard, Judson, Rosner, Kristen, Paruch, Kamil, Guzi, Timothy J
Format: Article
Language:English
Subjects:
Analogs
Derivatives
Displacement
Nucleosides
Tetrahedrons
Online Access:Get full text
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Summary:A novel class of 5'-amino-2',5'-dideoxy-2',2'-dif luorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to provide the desired derivatives.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.11.018