Efficient synthesis of 2,3-unsaturated sulfonamidoglycosides by Amberlyst 15

Sulfonamidoglycosylation of glycals in the presence of Amberlyst 15 proceeded effectively to afford the sulfonamidoglycosides in good to high yields. Two N-glycosyl sulfonamides are inhibitors of tumor cell growth in the micromolar range. Sulfonamidoglycosylation of d-glycals in the presence of Ambe...

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Bibliographic Details
Published in:Tetrahedron letters 2010-10, Vol.51 (41), p.5372-5374
Main Authors: Témpera, Carlos A., Colinas, Pedro A., Bravo, Rodolfo D.
Format: Article
Language:English
Subjects:
Antiproliferatives
In vitro testing
Inhibitors
Reaction time
Synthesis (chemistry)
Tetrahedrons
Tumors
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Summary:Sulfonamidoglycosylation of glycals in the presence of Amberlyst 15 proceeded effectively to afford the sulfonamidoglycosides in good to high yields. Two N-glycosyl sulfonamides are inhibitors of tumor cell growth in the micromolar range. Sulfonamidoglycosylation of d-glycals in the presence of Amberlyst 15 proceeded effectively to afford the sulfonamidoglycosides in good to high yields with minimal workup and short reaction times. Two N-glycosyl sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.07.076