Nano-copper catalyzed three-component reaction to construct 1,4-substituted 1,2,3-triazoles

Three-component reaction of alkyl halides, sodium azide with terminal alkynes can be catalyzed by nano-copper particles under ambient conditions. A series of 1,4-disubstituted-1,2,3-triazoles were obtained regioselectively by this one-pot strategy. Nano copper can be reused at least three times with...

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Bibliographic Details
Published in:Tetrahedron letters 2014-04, Vol.55 (14), p.2312-2316
Main Authors: Huang, Lina, Liu, Wei, Wu, Juncheng, Fu, Ying, Wang, Kehu, Huo, Congde, Du, Zhengyin
Format: Article
Language:English
Subjects:
Alkynes
Click chemistry
Copper nanoparticles
Cycloaddition
Deactivation
HALIDES
MICROSTRUCTURES
Multicomponent reaction
Nanostructure
Phenylacetylene
Sodium azides
Strategy
Terminals
Tetrahedrons
TRIAZOLE
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Summary:Three-component reaction of alkyl halides, sodium azide with terminal alkynes can be catalyzed by nano-copper particles under ambient conditions. A series of 1,4-disubstituted-1,2,3-triazoles were obtained regioselectively by this one-pot strategy. Nano copper can be reused at least three times without significant deactivation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.02.114