Synthesis of perimidine and 1,5-benzodiazepine derivatives using tamed Bronsted acid, BF3aH2O

The one pot synthesis of perimidine and 1,5-benzodiazepine derivatives via condensation of aryldiamines with ketones in the presence of BF3aH2O is described. BF3aH2O plays a dual role, as an efficient non-oxidizing Bronsted acid catalyst as well as an effective solvent making the reaction more econo...

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Bibliographic Details
Published in:Journal of fluorine chemistry 2013-08, Vol.152, p.99-105
Main Authors: Prakash, G K, Paknia, Farzaneh, Narayan, Arjun, Mathew, Thomas, Olah, George
Format: Article
Language:English
Subjects:
Catalysts
Condensing
Derivatives
Economics
Fluorine
Ketones
Solvents
Synthesis (chemistry)
Online Access:Get full text
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Summary:The one pot synthesis of perimidine and 1,5-benzodiazepine derivatives via condensation of aryldiamines with ketones in the presence of BF3aH2O is described. BF3aH2O plays a dual role, as an efficient non-oxidizing Bronsted acid catalyst as well as an effective solvent making the reaction more economic and environmentally safer. The reaction is simple, fast and convenient.
ISSN:0022-1139
DOI:10.1016/j.jfluchem.2013.03.023