In Vivo Remote Control of Reactions in Caenorhabditis elegans by Using Supramolecular Nanohybrids of Carbon Nanotubes and Liposomes

A supramolecular nanohybrid based on carbon nanotubes and liposomes that is highly biocompatible and capable of permeation through cells is described. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near‐infrared laser irradiation for the release...

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Bibliographic Details
Published in:Angewandte Chemie 2015-08, Vol.127 (34), p.10041-10044
Main Authors: Miyako, Eijiro, Chechetka, Svetlana A., Doi, Motomichi, Yuba, Eiji, Kono, Kenji
Format: Article
Language:eng ; ger
Subjects:
Biocompatibility
Carbon nanotubes
Chemistry
Controlled release
Gezielter Transport
Kohlenstoffnanoröhren
Lasers
Liposome
Liposomes
Nanostructure
Nanotechnologie
Nanotubes
Nematodes
Neuronen
Permeation
Surgical implants
Symbiosis
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Summary:A supramolecular nanohybrid based on carbon nanotubes and liposomes that is highly biocompatible and capable of permeation through cells is described. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near‐infrared laser irradiation for the release of molecules from the nanohybrids in a targeted manner via microscopy. We implemented the controlled release of molecules from the nanohybrids and demonstrated remote regulation of the photoinduced nanohybrid functions. As a proof of principle, nanohybrids loaded with amiloride were successfully used in the spatiotemporally targeted blocking of amiloride‐sensitive mechanosensory neurons in living Caenorhabditis elegans. Our prototype could inspire new designs for biomimetic parasitism and symbiosis, and biologically active nanorobots for the higher‐level manipulation of organisms. Aktiv durch Bestrahlung: Ein zellgängiges supramolekulares Nanohybrid aus biokompatiblen Kohlenstoffnanoröhren (CNT) und Liposom, das mit funktionellen Molekülen beladen werden kann, wurde entwickelt. Die lichtinduzierte Freisetzung von Amilorid (rote Sternchen), einer solchen funktionellen Fracht, inaktiviert Amilorid‐empfindliche Neuronen in C. elegans – ein Modell für biologisch aktive Nanoroboter, die Organismen manipulieren können.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201504987