A facile synthesis of benzo[b][1,4]thiazepine derivatives by palladium acetate catalyzed reaction

The preparation of steroid/nonsteroid fused benzo[b][1,4]thiazepines and 2-arylsubstituted benzo[b][1,4]thiazepines is described from Pd(OAc)2 catalyzed reaction of steroidal/nonsteroidal β-halovinyl aldehydes and 2-aminothiophenols in DMF under heating condition.

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Bibliographic Details
Published in:Tetrahedron letters 2014-03, Vol.55 (11), p.1927-1930
Main Authors: Kaishap, Partha Pratim, Shekarrao, Kommuri, Saikia, Pallabi, Gogoi, Sanjib, Boruah, Romesh C.
Format: Article
Language:English
Subjects:
2-Aminothiophenol
Acetates
Aldehydes
Benzo[b][1,4]thiazepine
Derivatives
Heating
Palladium
Palladium acetate
Steroid
Steroids
Synthesis (chemistry)
Tetrahedrons
β-Bromovinyl aldehyde
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Description
Summary:The preparation of steroid/nonsteroid fused benzo[b][1,4]thiazepines and 2-arylsubstituted benzo[b][1,4]thiazepines is described from Pd(OAc)2 catalyzed reaction of steroidal/nonsteroidal β-halovinyl aldehydes and 2-aminothiophenols in DMF under heating condition.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.01.153