New ruthenium(II) coordination compounds possessing bidentate aminomethylphosphane ligands: synthesis, characterization and preliminary biological study in vitro

• Published in: Dalton transactions : an international journal of inorganic chemistry 2015-08, Vol.44 (31), p.13969-13978
• Main Authors: Płotek, Michał, Starosta, Radosław, Komarnicka, Urszula K, Skórska-Stania, Agnieszka, Jeżowska-Bojczuk, Małgorzata, Stochel, Grażyna, Kyzioł, Agnieszka
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Apoproteins - metabolism; Biological; Cell Line, Tumor; Chemistry Techniques, Synthetic; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - metabolism; Coordination Complexes - pharmacology; Coordination compounds; Crystallography; Human; Humans; In vitro testing; Ligands; Models, Molecular; Molecular Conformation; Nitrogen atoms; Oxides - chemistry; Phosphines - chemistry; Reduction; Ruthenium - chemistry; Serum Albumin - metabolism; Synthesis; Transferrin - metabolism
• ISSN: 1477-9226; 1477-9234
• DOI: 10.1039/c5dt01119a

Addition of aminomethylphosphane P{CH2N(CH2CH2)2O}3 (), PPh2{CH2N(CH2CH2)2O} () or PPh2{CH2N(CH2CH2)2NCH2CH3} () to a methanolic solution of RuCl3 results in reduction of ruthenium(iii) ions giving finally ttt-[RuCl2()2] (), ttt-[RuCl2()2] () and ttt-[RuCl2()2] (). The synthesized complexes are the first examples of ruthenium(ii) coordination compounds possessing aminomethylphosphanes chelating via phosphorus and nitrogen atoms. They were fully characterized (NMR, ESI-MS, IR, elemental analysis, X-ray crystallography). Preliminary studies of the in vitro cytotoxicity on the A549 cell line (human lung adenocarcinoma) and interactions with human serum proteins (albumin and apotransferrin) showed moderate activity of the complexes. Interestingly, the P,N-chelation leads to formation of strained 4-membered Ru-P-C-N-Ru rings, which in the case of and undergo opening in the presence of CH3CN, which results in rearrangement to ctc-[RuCl2()2(CH3CN)2] () and ctc-[RuCl2()2(CH3CN)2] ().