Ligand-free palladium assisted insertion of isocyanides to urea derivatives for cascade synthesis of phenylamino-substituted quinazolinones

Palladium catalyzed cascade coupling of substituted urea derivatives and tert-butyl isocyanide for the efficient synthesis of phenylamino-substituted quinazolinones has been developed in moderate to good yields. This method provides a short and alternative approach for the synthesis of quinazolinone...

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Bibliographic Details
Published in:Tetrahedron letters 2014-10, Vol.55 (44), p.6051-6054
Main Authors: Sharma, Siddharth, Jain, Abhilasha
Format: Article
Language:English
Subjects:
Cascades
Derivatives
Insertion
Isocyanide insertion
Metal catalyzed
Palladium
Quinazolinone
Quinazolinones
Synthesis (chemistry)
Tetrahedrons
Ureas
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Summary:Palladium catalyzed cascade coupling of substituted urea derivatives and tert-butyl isocyanide for the efficient synthesis of phenylamino-substituted quinazolinones has been developed in moderate to good yields. This method provides a short and alternative approach for the synthesis of quinazolinones derivatives which are valuable compounds with biological and pharmacological potentials. A plausible mechanistic scheme is proposed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.09.027