Synthesis of a new urea derivative: a dual-functional organocatalyst for Knoevenagel condensation in water

A phenylalanine–urea compound-catalyzed Knoevenagel condensation in water is reported. Various aldehydes and active methylene compounds undergo condensation at room temperature to give the desired products in high yields. The mechanism of the condensation of aldehydes with Meldrum’s acid catalyzed b...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2013-09, Vol.54 (39), p.5370-5373
Main Authors: Le, Wen-Jun, Lu, Hong-Fei, Zhou, Jun-Tao, Cheng, He-Long, Gao, Yu-Hua
Format: Article
Language:English
Subjects:
Aldehydes
Aqueous
Condensates
Derivatives
Knoevenagel condensation
Methylene
Phenylalanine
Synthesis (chemistry)
Tetrahedrons
Urea compound
Ureas
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A phenylalanine–urea compound-catalyzed Knoevenagel condensation in water is reported. Various aldehydes and active methylene compounds undergo condensation at room temperature to give the desired products in high yields. The mechanism of the condensation of aldehydes with Meldrum’s acid catalyzed by the novel urea derivative is also disclosed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.07.116