Synthesis of leptosin, a glycoside isolated from mānuka honey

The first synthesis of leptosin, a novel glycoside isolated from mānuka honey is described. Utilising an acetyl protecting group strategy the glycoside was obtained with excellent anomeric selectivity by deploying a Schmidt glycosylation as a key step.

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2013-12, Vol.54 (50), p.6916-6919
Main Authors: Aitken, Harry R.M., Johannes, Manuel, Loomes, Kerry M., Brimble, Margaret A.
Format: Article
Language:English
Subjects:
Disaccharide
Glycosides
Glycosylation
Honey
Leptosin
Methyl syringate
Mānuka honey
Selectivity
Strategy
Synthesis (chemistry)
Tetrahedrons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The first synthesis of leptosin, a novel glycoside isolated from mānuka honey is described. Utilising an acetyl protecting group strategy the glycoside was obtained with excellent anomeric selectivity by deploying a Schmidt glycosylation as a key step.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.10.042