Catalyst-free synthesis of 3-(alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids via a three-component condensation

The synthesis of a number of 3-(alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids via a facile route involving the reaction between 2-amino-3-pyridinecarboxylic acid, benzaldehyde derivatives, and isonitriles is reported. The structures of the synthesized compounds are proved by X-ray crys...

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Bibliographic Details
Published in:Tetrahedron letters 2014-05, Vol.55 (19), p.3052-3054
Main Authors: Marandi, Ghasem, Saghatforoush, Lotfali, Mendoza-Meroño, Rafael, García-Granda, Santiago
Format: Article
Language:English
Subjects:
2-Amino-3-pyridinecarboxylic acid
3-(Alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids
Arylcarboxaldehydes
Benzaldehyde
Catalysts
Condensing
Crystallography
Derivatives
Isocyanides
Synthesis (chemistry)
Tetrahedrons
X-rays
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Summary:The synthesis of a number of 3-(alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids via a facile route involving the reaction between 2-amino-3-pyridinecarboxylic acid, benzaldehyde derivatives, and isonitriles is reported. The structures of the synthesized compounds are proved by X-ray crystallography.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.03.121