One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives

Herein, a protocol that involves microwave-assisted, multicomponent one-pot synthetic strategy for the construction of the medicinally important purine quinazolinone scaffold is reported. A series of compounds are prepared by cyclization and condensation reactions using this approach. The compounds...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2012-11, Vol.53 (46), p.6195-6198
Main Authors: Sawant, Sanghapal D., Srinivas, Mahesuni, Lakshma Reddy, G., Venkateswar Rao, V., Singh, Parvinder Pal, Vishwakarma, Ram A.
Format: Article
Language:English
Subjects:
Anticancer properties
Condensing
Derivatives
Inhibitors
Microwave
Multicomponent reaction
PI3K-δ inhibitors
Purine quinazolinone
Purines
Quinazolinones
Strategy
Tetrahedrons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herein, a protocol that involves microwave-assisted, multicomponent one-pot synthetic strategy for the construction of the medicinally important purine quinazolinone scaffold is reported. A series of compounds are prepared by cyclization and condensation reactions using this approach. The compounds are structural analogs of anticancer agents IC-87114 and CAL-101, which are highly isoform-selective PI3K-δ inhibitors and are presently under clinical investigation for chronic lymphocytic leukemia.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.08.137