Cyanation of indoles with benzyl cyanide as the cyanide anion surrogate

A copper-mediated direct cyanation of indoles with benzyl cyanide as the cyanide anion surrogate has been achieved. The cascade reaction furnished 3-cyanoindoles under mild reaction conditions in good to excellent yields with various functional groups tolerance. [Display omitted]

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Bibliographic Details
Published in:Tetrahedron 2013-05, Vol.69 (21), p.4236-4240
Main Authors: Zhang, Lianpeng, Wen, Qiaodong, Jin, Jisong, Wang, Chen, Lu, Ping, Wang, Yanguang
Format: Article
Language:English
Subjects:
3-Cyanoindoles
Anions
Benzyl cyanide
Cascade chemical reactions
Copper catalysis
Cyanation
Cyanides
Functional groups
Indoles
Tetrahedrons
Tolerances
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Description
Summary:A copper-mediated direct cyanation of indoles with benzyl cyanide as the cyanide anion surrogate has been achieved. The cascade reaction furnished 3-cyanoindoles under mild reaction conditions in good to excellent yields with various functional groups tolerance. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.03.089