Preparation of phenolic compounds through catalyst-free ipso-hydroxylation of arylboronic acids

A novel method for the preparation of phenolic compounds through ipso-hydroxylation of the corresponding widely available arylboronic acid precursors is described. Through application of a novel PEG400-H2O2 reactant system, a variety of substituted phenols and other aromatic analogues have been prep...

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Bibliographic Details
Published in:Tetrahedron letters 2014-03, Vol.55 (13), p.2082-2084
Main Authors: Gohain, Mukut, du Plessis, Maretha, van Tonder, Johannes H., Bezuidenhoudt, Barend C.B.
Format: Article
Language:English
Subjects:
Arylboronic acid
Catalyst-free
Catalysts
Hydrogen peroxide
Hydroxylation
Phenolic compounds
Phenols
Polyethylene glycol
Precursors
Tetrahedrons
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Summary:A novel method for the preparation of phenolic compounds through ipso-hydroxylation of the corresponding widely available arylboronic acid precursors is described. Through application of a novel PEG400-H2O2 reactant system, a variety of substituted phenols and other aromatic analogues have been prepared in excellent yields at room temperature in the absence of any catalyst.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.02.048