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Convenient detection of metal-DNA, metal-RNA, and metal-protein adducts with a click-modified Pt(II) complex
cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA. Pt-protein adducts are detected using BSA as a model. Following in...
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| Published in: | Dalton transactions : an international journal of inorganic chemistry 2015-02, Vol.44 (8), p.3536-3539 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c430t-d798c1d359caa07819032d235399b692bb573268326647dea3750ba7f6401af43 |
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| cites | cdi_FETCH-LOGICAL-c430t-d798c1d359caa07819032d235399b692bb573268326647dea3750ba7f6401af43 |
| container_end_page | 3539 |
| container_issue | 8 |
| container_start_page | 3536 |
| container_title | Dalton transactions : an international journal of inorganic chemistry |
| container_volume | 44 |
| creator | Moghaddam, Alan D White, Jonathan D Cunningham, Rachael M Loes, Andrea N Haley, Michael M DeRose, Victoria J |
| description | cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA. Pt-protein adducts are detected using BSA as a model. Following in vivo treatment, long-lived Pt-RNA adducts are detected on ribosomal RNA. |
| doi_str_mv | 10.1039/c4dt02649g |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2015-02, Vol.44 (8), p.3536-3539 |
| issn | 1477-9226 1477-9234 |
| language | eng |
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| source | Royal Society of Chemistry |
| subjects | Adducts Animals Bias Cattle Click Chemistry Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Deoxyribonucleic acid DNA - chemistry DNA Adducts - chemistry Fluorescence Hydrazines - chemistry Isomers Labelling Platinum Platinum - chemistry Proteins - chemistry Proteins - metabolism Ribonucleic acids RNA - chemistry Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism |
| title | Convenient detection of metal-DNA, metal-RNA, and metal-protein adducts with a click-modified Pt(II) complex |
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