Facile functionalization at the C2 position of a highly substituted benzofuran

To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently.

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Bibliographic Details
Published in:Tetrahedron letters 2014-04, Vol.55 (14), p.2212-2216
Main Authors: He, Shuwen, Li, Peng, Dai, Xing, McComas, Casey C., Du, Chunyan, Wang, Ping, Lai, Zhong, Liu, Hong, Yin, Jingjun, Bulger, Paul G., Dang, Qun, Xiao, Dong, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan
Format: Article
Language:English
Subjects:
Benzofuran
Iodides
Precursors
Substituted 2-iodobenzofuran
Substituted benzofuran-2-ylboronic acid
Suzuki coupling
Tetrahedrons
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Description
Summary:To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.02.051