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Facile functionalization at the C2 position of a highly substituted benzofuran

To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently.

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Published in:Tetrahedron letters 2014-04, Vol.55 (14), p.2212-2216
Main Authors: He, Shuwen, Li, Peng, Dai, Xing, McComas, Casey C., Du, Chunyan, Wang, Ping, Lai, Zhong, Liu, Hong, Yin, Jingjun, Bulger, Paul G., Dang, Qun, Xiao, Dong, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan
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cited_by cdi_FETCH-LOGICAL-c339t-7afe5ab46c0f18c2abc613a9a450b2e0c7ade661e077598a8adf300e877bad783
cites cdi_FETCH-LOGICAL-c339t-7afe5ab46c0f18c2abc613a9a450b2e0c7ade661e077598a8adf300e877bad783
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container_issue 14
container_start_page 2212
container_title Tetrahedron letters
container_volume 55
creator He, Shuwen
Li, Peng
Dai, Xing
McComas, Casey C.
Du, Chunyan
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Lai, Zhong
Liu, Hong
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Dang, Qun
Xiao, Dong
Zorn, Nicolas
Peng, Xuanjia
Nargund, Ravi P.
Palani, Anandan
description To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently.
doi_str_mv 10.1016/j.tetlet.2014.02.051
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ispartof Tetrahedron letters, 2014-04, Vol.55 (14), p.2212-2216
issn 0040-4039
1873-3581
language eng
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source ScienceDirect Journals
subjects Benzofuran
Iodides
Precursors
Substituted 2-iodobenzofuran
Substituted benzofuran-2-ylboronic acid
Suzuki coupling
Tetrahedrons
title Facile functionalization at the C2 position of a highly substituted benzofuran
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