Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation

A concise total synthesis of the 11-membered cyclic (+)-aspercyclide C is reported. Key to success was the fine-tuning of the reaction media to realize an oxidative, macrocyclic diaryl C-O bond formation in a regioselective and direct fashion.

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Bibliographic Details
Published in:Chemistry letters 2014-03, Vol.43 (3), p.349-349
Main Authors: Yoshino, Tatsuya, Yamashita, Shuji, Sato, Itaru, Hayashi, Yujiro, Hirama, Masahiro
Format: Article
Language:English
Subjects:
Bonding
Diaryl ethers
Formations
Media
Synthesis
Tuning
Online Access:Get full text
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Description
Summary:A concise total synthesis of the 11-membered cyclic (+)-aspercyclide C is reported. Key to success was the fine-tuning of the reaction media to realize an oxidative, macrocyclic diaryl C-O bond formation in a regioselective and direct fashion.
ISSN:0366-7022
1348-0715