Dinuclear [{(p-cym)RuCl} sub(2)( mu -ph py)](PF sub(6)) sub(2) and heterodinuclear [(ppy) sub(2)Ir( mu -phpy)Ru(p-cym)Cl](PF sub(6)) sub(2) complexes: synthesis, structure and anticancer activity

Phpy bridged homodinuclear Ru-Ru (1) and heterodinuclear Ir-Ru complexes (2) have been developed. Complex 2 induces autophagy towards the cisplatin resistant human breast cancer (MCF7) cell line, whereas 1 is inactive.

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2014-09, Vol.43 (39), p.14546-14549
Main Authors: Tripathy, Suman Kumar, De, Umasankar, Dehury, Niranjan, Pal, Satyanarayan, Kim, Hyung Sik, Patra, Srikanta
Format: Article
Language:English
Subjects:
Anticancer properties
Biotechnology
Breast
Cancer
Human
Synthesis (chemistry)
Online Access:Get full text
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Description
Summary:Phpy bridged homodinuclear Ru-Ru (1) and heterodinuclear Ir-Ru complexes (2) have been developed. Complex 2 induces autophagy towards the cisplatin resistant human breast cancer (MCF7) cell line, whereas 1 is inactive.
ISSN:1477-9226
1477-9234
DOI:10.1039/c4dt01033g