Development of a chalconeatriazine fusion library: combination of a fluorophore and biophore

A chalconeatriazine fusion library has been developed. We designed fused chalconeatriazine structure by combining a fluorophore and a biophore for imaging and biological probe development. Through solid support chemistry, 80 compounds with amine building blocks were synthesized. Spectroscopic studie...

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Bibliographic Details
Published in:Tetrahedron letters 2013-06, Vol.54 (23), p.2976-2979
Main Authors: Lee, Sung-Chan, Zhai, Duanting, Chang, Young-Tae
Format: Article
Language:English
Subjects:
Amines
Biological
Chemical compounds
Fluorescence
Imaging
Libraries
Spectroscopy
Tetrahedrons
Online Access:Get full text
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Summary:A chalconeatriazine fusion library has been developed. We designed fused chalconeatriazine structure by combining a fluorophore and a biophore for imaging and biological probe development. Through solid support chemistry, 80 compounds with amine building blocks were synthesized. Spectroscopic studies and cell image testing of the compounds showed their potential to be used as probes for bio-imaging.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.03.129