Loading…

One pot conjugation of small molecules to RNA using click chemistry

A convenient, one step conjugation method based on click chemistry has been developed for creating new RNA conjugates. The coupling reaction was performed in RNA 2′-hydroxy deprotection solution, with conjugation and TBDMS-deprotection being accomplished at the same time.

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2012-12, Vol.53 (50), p.6747-6750
Main Authors: Wang, Wei, Chen, Ke, Qu, Dezhong, Chi, Weilin, Xiong, Wei, Huang, Yanxiang, Wen, Jian, Feng, Shipeng, Zhang, Biliang
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A convenient, one step conjugation method based on click chemistry has been developed for creating new RNA conjugates. The coupling reaction was performed in RNA 2′-hydroxy deprotection solution, with conjugation and TBDMS-deprotection being accomplished at the same time.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.09.128