Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium

Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, an endophytic fungus of Gongronema latifolium, afforded three new secondary metabolites, including corynesidone D (1), corynether B (2) and corynether lactone A (3), together with four known derivatives. The structures of...

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Bibliographic Details
Published in:Tetrahedron letters 2013-08, Vol.54 (32), p.4210-4214
Main Authors: Okoye, Festus Basden C., Lu, Su, Nworu, Chukwuemeka S., Esimone, Charles O., Proksch, Peter, Chadli, Ahmed, Debbab, Abdessamad
Format: Article
Language:English
Subjects:
Corynespora cassiicola
Derivatives
Diaryl ethers
Endophytes
Fungi
Heat shock protein 90 (Hsp90)
Lactones
Mass spectrometry
Metabolites
NMR spectroscopy
Structure elucidation
Tetrahedrons
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Summary:Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, an endophytic fungus of Gongronema latifolium, afforded three new secondary metabolites, including corynesidone D (1), corynether B (2) and corynether lactone A (3), together with four known derivatives. The structures of the new compounds were deduced on the basis of 1D- and 2D-dimensional NMR spectroscopy as well as by high resolution mass spectrometry. Compounds 1 and 4–6 were tested for their ability to modulate the chaperoning activity of the Hsp90 chaperoning machine in vitro using 17-allylamino-demethoxygeldamycin (17-AAG) as a positive control. Unfortunately, no effect on the Hsp90 chaperoning machine has been observed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.05.117