N-Demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus

The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Ad...

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Bibliographic Details
Published in:Tetrahedron letters 2013-09, Vol.54 (38), p.5197-5200
Main Authors: Vallejo, Mariana G., Ortega, Maria Gabriela, Cabrera, José L., Agnese, Alicia Mariel
Format: Article
Language:English
Subjects:
Acetylcholinesterase inhibition
Alkaloids
Correlation
Huperzia saururus
N-Demethyl-sauroxine
Nuclear magnetic resonance
Sauroxine NMR two dimensional data
Spectra
Stereochemistry
Tetrahedrons
Two dimensional
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Summary:The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50=209.6±1.1μM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.07.068