A modular approach toward the synthesis of 2,4-disubstituted pyridines

A number of 2,4-disubstituted pyridines have been synthesized using α,β,γ,δ-unsaturated aldehydes and ammonium chloride in the presence of triethylamine in acetonitrile solvent at 80°C under air balloon.

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Bibliographic Details
Published in:Tetrahedron letters 2013-09, Vol.54 (36), p.4841-4843
Main Authors: Singha, Raju, Dhara, Shubhendu, Ray, Jayanta K.
Format: Article
Language:English
Subjects:
2,3-Disubstituted pyrrole
2,4-Disubstituted pyridine
Acetonitrile
Ammonium chlorides
Balloons
Electrocyclization
Imine
Modular
Pyridines
Solvents
Synthesis (chemistry)
Tetrahedrons
α,β,γ,δ-Unsaturated aldehyde
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Description
Summary:A number of 2,4-disubstituted pyridines have been synthesized using α,β,γ,δ-unsaturated aldehydes and ammonium chloride in the presence of triethylamine in acetonitrile solvent at 80°C under air balloon.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.06.092