Fabrication of Molecularly Imprinted Electrochemiluminescence Sensor and Its Application in Heroin Detection

An electrochemiluminescence (ECL) sensor with molecularly imprinted polymer (MIP) film was prepared for the determination of heroin. The sensor was prepared by re-modifying the molecular imprinting membrane onto the Ru (bpy)... modified glassy carbon electrode. The electrochemical and electrochemilu...

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Bibliographic Details
Published in:Fēnxī huàxué 2014-01, Vol.42 (6), p.904-908
Main Authors: SHANG, Zhe-Yi, HAN, Chao-Feng, SONG, Qi-Jun
Format: Article
Language:English
Subjects:
Electrochemiluminescence
Electrodes
Glassy carbon
Imprinted polymers
Narcotics
Optimization
Saliva
Sensors
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Summary:An electrochemiluminescence (ECL) sensor with molecularly imprinted polymer (MIP) film was prepared for the determination of heroin. The sensor was prepared by re-modifying the molecular imprinting membrane onto the Ru (bpy)... modified glassy carbon electrode. The electrochemical and electrochemiluminescence behavior of the sensor was investigated. The proposed sensor displayed high sensitivity and excellent selectivity for the target molecule heroin. Under the optimum conditions (0. 1 mol/L PBS (pH 7.0) at a scan rates of 100 mV/s and incubation time of 5 min), a linear response was observed with the concentrations of heroin from 1. 0 x 10 super(-14) mol/L to 1.0 x 10 super(-10) mol/L and the detection limit was 4.0 X 10 super(-15) mol/L. The sensor was successfully applied to the determination of heroin in urineand saliva samples with the recoveries from 97% to 104%.
ISSN:0253-3820
DOI:10.3724/SP.J.1096.2014.31193