Cytotoxic sesquiterpenoids from Sarcandra glabra

Five new sesquiterpenoid dimers, sarcandrolides F−J (1−5), three new sesquiterpenoid monomers (6−8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. The absolute configurations of compounds 1−5 were established by the CD exciton chirality method. Compound 1 re...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2013-01, Vol.69 (2), p.564-569
Main Authors: Ni, Gang, Zhang, Hua, Liu, Hong-Chun, Yang, Sheng-Ping, Geng, Mei-Yu, Yue, Jian-Min
Format: Article
Language:English
Subjects:
Bearing
Biotechnology
CD exciton chirality
Chirality
Dimers
Excitation
Monomers
Sarcandra glabra
Sarcandralactones C−E
Sarcandrolides F−J
Sesquiterpenoid dimers
Structural elucidation
Tetrahedrons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Five new sesquiterpenoid dimers, sarcandrolides F−J (1−5), three new sesquiterpenoid monomers (6−8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. The absolute configurations of compounds 1−5 were established by the CD exciton chirality method. Compound 1 represents the first example of a lindenane-type sesquiterpenoid dimer bearing a hydroperoxy group at C-5. Compounds 1 and 3 exhibited cytotoxicity against the HL-60 cell line with IC50 values of 0.03 and 1.2 μM, respectively. [Display omitted] Five new sesquiterpenoid dimers, sarcandrolides F−J (1−5), three new sesquiterpenoid monomers (6−8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. Compound 1 represents the first example of a lindenane-type sesquiterpenoid dimer bearing a hydroperoxy group at C-5. Compounds 1 and 3 exhibited cytotoxicity against the HL-60 cell line with IC50 values of 0.03 and 1.2 μM, respectively.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2012.11.023