Ruthenium-catalyzed benzimidazoisoquinoline synthesis via oxidative coupling of 2-arylbenzimidazoles with alkynes

Synthesis of a fused bis-heterocyclic framework, benzimidazoisoquinoline, has been achieved using Ru-catalyzed reaction of alkynes with 2-aryl benzimidazoles in the presence of Cu salts. The method provides an easy access for the generation of a library of benzimidazoisoquinoline derivatives.

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Bibliographic Details
Published in:Tetrahedron letters 2013-08, Vol.54 (32), p.4198-4201
Main Authors: Kavitha, Nerella, Sukumar, Genji, Kumar, Vemula Praveen, Mainkar, Prathama S., Chandrasekhar, Srivari
Format: Article
Language:English
Subjects:
Alkynes
Benzimidazoisoquinoline
Copper
C–H activation
Derivatives
Joining
Libraries
Oxidative coupling
PEG-400
Synthesis (chemistry)
Tetrahedrons
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Description
Summary:Synthesis of a fused bis-heterocyclic framework, benzimidazoisoquinoline, has been achieved using Ru-catalyzed reaction of alkynes with 2-aryl benzimidazoles in the presence of Cu salts. The method provides an easy access for the generation of a library of benzimidazoisoquinoline derivatives.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.05.106