Preyssler catalyst-promoted rapid, clean, and efficient condensation reactions for 3H-1,5-benzodiazepine synthesis in solvent-free conditions

A simple, convenient, and environmentally benign synthesis of 1,5-benzodiazepines is developed by condensing different o-phenylenediamines and 1,3-aryl-1,3-propanodiones. The reaction is catalyzed by a Preyssler (NaH14P5W30O110, HPA) heteropolyacid as a safe, clean, and recyclable catalyst. The meth...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2013-11, Vol.54 (48), p.6574-6579
Main Authors: Pasquale, Gustavo A., Ruiz, Diego M., Jios, Jorge L., Autino, Juan C., Romanelli, Gustavo P.
Format: Article
Language:English
Subjects:
1,3-Diaryl-1,3-propanediones
3H-1,5-Benzodiazepines
Catalysts
Cleaning
Condensing
o-Phenylenediamine
Preyssler catalyst
Solvent-free
Synthesis (chemistry)
Tetrahedrons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple, convenient, and environmentally benign synthesis of 1,5-benzodiazepines is developed by condensing different o-phenylenediamines and 1,3-aryl-1,3-propanodiones. The reaction is catalyzed by a Preyssler (NaH14P5W30O110, HPA) heteropolyacid as a safe, clean, and recyclable catalyst. The method is operationally simple and provides access to a variety of 1,5-benzodiazepines in good to excellent yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.09.101