The synthesis and evaluation of unsymmetrical dimeric X-ray contrast agents

Novel dimeric iodinated contrast agents with low osmolality have been prepared and evaluated with the aim of improving the already good safety profile of such agents. The aim of low osmolality was achieved, and the viscosity of these dimeric agents was also found to be beneficially lower than curren...

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Published in:Tetrahedron letters 2011-06, Vol.52 (24), p.3068-3071
Main Authors: Wynn, Duncan G., Humphries, Gareth, Morisson-Iveson, Véronique, Nairne, James, Newington, Ian M., Passmore, Joanna, Wistrand, Lars-Göran
Format: Article
Language:English
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Summary:Novel dimeric iodinated contrast agents with low osmolality have been prepared and evaluated with the aim of improving the already good safety profile of such agents. The aim of low osmolality was achieved, and the viscosity of these dimeric agents was also found to be beneficially lower than current dimeric agents in clinical use.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.04.009