Synthesis of I--di or trisubstituted (tetrahydrofuran-2-yl)methanols via photoinduced additive-free intermolecular addition of THF to aromatic aldehydes or ketones

THF is found to react with aromatic aldehydes or ketones highly chemoselectively under the irradiation of ultraviolet without any additives, which provides a new protocol to access I--di or trisubstituted (tetrahydrofuran-2-yl)methanols. The scope of this reaction is well studied.

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Bibliographic Details
Published in:Tetrahedron letters 2013-12, Vol.54 (50), p.6964-6966
Main Authors: Hao, Xinqi, Liu, Chaoli, Liu, Chenli, Chen, Yiyong, Zhao, Xuemei, Song, Maoping, Qian, Rong, Guo, Hao
Format: Article
Language:English
Subjects:
Additives
Aldehydes
Irradiation
Ketones
Synthesis (chemistry)
Tetrahedrons
Tetrahydrofuran
Ultraviolet
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Description
Summary:THF is found to react with aromatic aldehydes or ketones highly chemoselectively under the irradiation of ultraviolet without any additives, which provides a new protocol to access I--di or trisubstituted (tetrahydrofuran-2-yl)methanols. The scope of this reaction is well studied.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.10.063