Rapid and sensitive fluorescent probes for monoamine oxidases B to A at low concentrations

A new monoamine oxidase (MAO) fluorescent probe that displays response for both monoamine oxidase type-A (MAO-A) and monoamine oxidase type-B (MAO-B) is reported. This sensing platform does not require any additional enzymes or reagents. Furthermore, the probes have better sensitivity and shorter re...

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Bibliographic Details
Published in:Tetrahedron letters 2012-12, Vol.53 (51), p.6881-6884
Main Authors: Zhang, Yexiang, Xu, Yufang, Tan, Shaoying, Xu, Lin, Qian, Xuhong
Format: Article
Language:English
Subjects:
Coumarin derivatives
Differentiation
Displays
Enzymes
Fluorescence
Fluorescent probes
Low concentrations
Monoamine oxidase type-B
Optimization
Oxidase
Platforms
Tetrahedrons
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Description
Summary:A new monoamine oxidase (MAO) fluorescent probe that displays response for both monoamine oxidase type-A (MAO-A) and monoamine oxidase type-B (MAO-B) is reported. This sensing platform does not require any additional enzymes or reagents. Furthermore, the probes have better sensitivity and shorter response time by comparison with similar probes, and have potentials in differentiation of MAO-A and MAO-B upon further optimization.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.09.074