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The first examples of seco-prezizaane-type norsesquiterpenoids with neurotrophic activity from Illicium jiadifengpi

Two seco-prezizaane-type sesquiterpenoids (2R)-hydroxy-norneomajucin (1) and jiadifenone (2) that represent the first examples of nor-type were isolated from the methanol extract of the pericarps of Illicium jiadifengpi. Their structures and the absolute configuration of 1 were established by the an...

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Bibliographic Details
Published in:Tetrahedron letters 2012-03, Vol.53 (10), p.1231-1235
Main Authors: Kubo, Miwa, Kobayashi, Kana, Huang, Jian-Mei, Harada, Kenichi, Fukuyama, Yoshiyasu
Format: Article
Language:English
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Summary:Two seco-prezizaane-type sesquiterpenoids (2R)-hydroxy-norneomajucin (1) and jiadifenone (2) that represent the first examples of nor-type were isolated from the methanol extract of the pericarps of Illicium jiadifengpi. Their structures and the absolute configuration of 1 were established by the analysis of spectroscopic data and chemical conversion of (2S)-hydroxyneomajucin to 1, respectively. In addition, compound 1 exhibited neurotrophic activity to significantly promote neurite outgrowth in the primary cultured rat cortical neurons at concentrations ranging from 1 to 10μmolL−1.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.12.107