Recent trends in the development of vitamin B sub(12) derivatives for medicinal applications

This Feature Article highlights recent developments in the field of vitamin B sub(12) derivatives for medicinal applications. The following topics are emphasized: (1) the development of aquacorrinoids for cyanide detection and detoxification, (2) the use of vitamin B sub(12) conjugates and (3) antiv...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (74), p.14004-14017
Main Author: Zelder, Felix
Format: Article
Language:English
Subjects:
Conjugates
Cyanides
Derivatives
Diagnosis
Therapy
Trends
Vitamin B12
Online Access:Get full text
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Summary:This Feature Article highlights recent developments in the field of vitamin B sub(12) derivatives for medicinal applications. The following topics are emphasized: (1) the development of aquacorrinoids for cyanide detection and detoxification, (2) the use of vitamin B sub(12) conjugates and (3) antivitamins B sub(12) for therapy and diagnosis, and (4) the design of corrinoids as activators of soluble guanylyl cyclase (sGC).
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04843e