Random and aligned PLLA : PRGF electrospun scaffolds for regenerative medicine

ABSTRACT Random and aligned electrospun scaffolds were prepared combining poly(l‐lactic acid) (PLLA) and activated platelet‐rich plasma (PRGF) at various proportions, with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is relea...

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Bibliographic Details
Published in:Journal of applied polymer science 2015-02, Vol.132 (5), p.np-n/a
Main Authors: Díaz-Gómez, Luis, Ballarin, Florencia Montini, Abraham, Gustavo A., Concheiro, Angel, Alvarez-Lorenzo, Carmen
Format: Article
Language:English
Subjects:
Alignment
Attachment
biomaterials
Electrospinning
Encapsulation
fibers
Growth factors
Materials science
Nanofibers
Orientation
polyesters
Polymers
proteins
Scaffolds
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Summary:ABSTRACT Random and aligned electrospun scaffolds were prepared combining poly(l‐lactic acid) (PLLA) and activated platelet‐rich plasma (PRGF) at various proportions, with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is released from scaffolds in a sustained way for at least 3 weeks, without an initial burst effect. Mesenchymal stem cells (MSCs) seeded on the random scaffolds present a polygonal and random orientation in any direction of the scaffold. On the other hand, aligned scaffolds are able to promote cell attachment and proliferation in the direction of the nanofibers. The incorporation of PRGF in the scaffolds enhances cell proliferation for at least 2 weeks. Overall, aligned electrospun PLLA : PRGF scaffolds can encapsulate growth factors at relatively large proportions and sustain their release to enhance cell attachment and proliferation as well as eliciting cell alignment. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41372.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.41372