An efficient three-component synthesis of coumarin-3-carbamides by use of Ni–NiO nanoparticles as magnetically separable catalyst

An efficient and ecofriendly synthesis of coumarin-3-carbamides, a class of compounds known for their remarkable biological activities and fluorescent properties, has been developed by a three-component reaction of 2-hydroxybenzaldehydes, aliphatic primary/secondary amines and diethyl malonate using...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (87), p.70718-70725
Main Authors: Sepay, Nayim, Guha, Chayan, Kool, Arpan, Mallik, Asok K.
Format: Article
Language:English
Subjects:
Aliphatic compounds
Catalysts
Ethanol
Ethyl alcohol
Nanoparticles
Nickel
Solvents
Synthesis
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Summary:An efficient and ecofriendly synthesis of coumarin-3-carbamides, a class of compounds known for their remarkable biological activities and fluorescent properties, has been developed by a three-component reaction of 2-hydroxybenzaldehydes, aliphatic primary/secondary amines and diethyl malonate using Ni–NiO nanoparticles as catalyst in the green solvent ethanol. The method is compatible with various functional groups and moieties.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA13932E