Analytical model of diffuse reflectance spectrum of skin tissue

We have derived simple analytical expressions that enable highly accurate calculation of diffusely reflected light signals of skin in the spectral range from 450 to at a distance from the region of delivery of exciting radiation. The expressions, taking into account the dependence of the detected si...

Full description

Saved in:
Bibliographic Details
Published in:Quantum electronics (Woodbury, N.Y.) N.Y.), 2014-01, Vol.44 (1), p.69-75
Main Authors: Lisenko, S.A., Kugeiko, M.M., Firago, V.A., Sobchuk, A.N.
Format: Article
Language:English
Subjects:
ABSORPTION
Absorption coefficient
analytical model
APPROXIMATIONS
BILIRUBIN
biophysical parameters
Computer simulation
CONCENTRATION RATIO
diffuse reflectance
Diffusion
EPIDERMIS
Exact solutions
LIGHT SCATTERING
Mathematical analysis
Mathematical models
MONTE CARLO METHOD
PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
Reflectance
REFRACTIVE INDEX
SIMULATION
skin
SPECTRA
SPECTROPHOTOMETERS
VISIBLE RADIATION
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have derived simple analytical expressions that enable highly accurate calculation of diffusely reflected light signals of skin in the spectral range from 450 to at a distance from the region of delivery of exciting radiation. The expressions, taking into account the dependence of the detected signals on the refractive index, transport scattering coefficient, absorption coefficient and anisotropy factor of the medium, have been obtained in the approximation of a two-layer medium model (epidermis and dermis) for the same parameters of light scattering but different absorption coefficients of layers. Numerical experiments on the retrieval of the skin biophysical parameters from the diffuse reflectance spectra simulated by the Monte Carlo method show that commercially available fibre-optic spectrophotometers with a fixed distance between the radiation source and detector can reliably determine the concentration of bilirubin, oxy- and deoxyhaemoglobin in the dermis tissues and the tissue structure parameter characterising the size of its effective scatterers. We present the examples of quantitative analysis of the experimental data, confirming the correctness of estimates of biophysical parameters of skin using the obtained analytical expressions.
ISSN:1063-7818
1468-4799
DOI:10.1070/QE2014v044n01ABEH015233