Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants

Effects of postnatal exposure to polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on thyroid hormone status were studied in the peripheral blood of 36 breast-fed Japanese infants. Estimated total intakes of these chemi...

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Bibliographic Details
Published in:Chemosphere (Oxford) 1998-10, Vol.37 (9), p.1789-1793
Main Authors: Nagayama, Junya, Okamura, Ken, Iida, Takao, Hirakawa, Hironori, Matsueda, Takahiko, Tsuji, Hiroshi, Hasegawa, Mayumi, Sato, Kayo, Ma, Using-Yi, Yanagawa, Takashi, Igarashi, Hisaji, Fukushige, Jun'ichiro, Watanabe, Tadayoshi
Format: Article
Language:English
Subjects:
Adult
Benzofurans - adverse effects
Biological and medical sciences
Breast Feeding
Coplanar PCBs
Environmental Exposure
Environmental pollutants toxicology
Female
General aspects
Humans
Infant
Infant, Newborn
Japan
Japanese infants
Lactational exposure
Male
Medical sciences
Milk, Human - chemistry
Polychlorinated Biphenyls - adverse effects
Polychlorinated dibenzo- p-dioxins
Polychlorinated Dibenzodioxins - adverse effects
Polychlorinated Dibenzodioxins - analogs & derivatives
Polychlorinated dibenzofurans
Thyroid Function Tests
thyroid hormone
Thyroid hormones
Thyroid Hormones - analysis
Thyroid Hormones - metabolism
Toxicology
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Summary:Effects of postnatal exposure to polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on thyroid hormone status were studied in the peripheral blood of 36 breast-fed Japanese infants. Estimated total intakes of these chemicals in toxic equivalent quantity (TEQ) converted into 2,3,7,8-tetrachlorodibenzo- p-dioxin (2,3,7,8-TCDD) from the breast milk significantly and negatively correlated with the levels of triiodothyronine (T 3) and thyroxme (T 4) in the blood of breast-fed babies. Therefore, exposure to background levels of the highly toxic organochlorine chemicals through the breast milk may cause some effects on thyroid hormone status in Japanese infants.
ISSN:0045-6535
1879-1298
DOI:10.1016/S0045-6535(98)00244-6