Scopolamine-induced convulsions in fasted mice after food intake: effects of glucose intake, antimuscarinic activity and anticonvulsant drugs

The present study was performed to further evaluate the contribution of antimuscarinic activity and hypoglycaemia to the development of scopolamine-induced convulsions in fasted mice after food intake. The effects of anticonvulsant drugs on convulsions were also evaluated. Antimuscarinic drugs atrop...

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Bibliographic Details
Published in:Neuropharmacology 2005-09, Vol.49 (3), p.293-299
Main Authors: Enginar, Nurhan, Nurten, Asiye, Yamantürk Çelik, Pınar, Açıkmeşe, Barış
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants
Anticonvulsants - administration & dosage
Anticonvulsants - pharmacology
Antimuscarinic activity
Biperiden - pharmacology
Eating - physiology
Fasting
Food intake
Glucose - administration & dosage
Glucose - pharmacology
Glucose intake
Hypoglycemia - chemically induced
Hypoglycemia - psychology
Male
Mice
Mice, Inbred BALB C
Muscarinic Antagonists - pharmacology
Myoclonus - chemically induced
Myoclonus - physiopathology
Scopolamine Hydrobromide - pharmacology
Scopolamine-induced convulsions
Seizures - chemically induced
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Summary:The present study was performed to further evaluate the contribution of antimuscarinic activity and hypoglycaemia to the development of scopolamine-induced convulsions in fasted mice after food intake. The effects of anticonvulsant drugs on convulsions were also evaluated. Antimuscarinic drugs atropine (3 mg/kg) and biperiden (10 mg/kg) were given intraperitoneally (i.p) to animals fasted for 48 h. Like scopolamine, both drugs induced convulsions after animals were allowed to eat ad libitum. Another group of animals was given glucose (5%) in drinking water during fasting. These animals, although they had normoglycaemic blood levels after fasting, also developed convulsions after treated with scopolamine i.p. (3 mg/kg), atropine (3 mg/kg) or biperiden (10 mg/kg) and allowed to eat ad libitum. Among the drugs studied, only valproate (340 mg/kg), gabapentin (50 mg/kg) and diazepam (2.5 and 5 mg/kg) markedly reduced the incidence of scopolamine-induced convulsions. The present results indicate that antimuscarinic activity, but not hypoglycaemia, underlies these convulsions which do not respond to most of the conventional anticonvulsant drugs.
ISSN:0028-3908
1873-7064
DOI:10.1016/j.neuropharm.2005.01.032