Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1α in cancer : Role of free radical formation

Widespread expression of the α-subunit of hypoxia-inducible factor (HIF-1α) was observed in samples of human oral squamous cell carcinoma. In all the cases, this was accompanied by a widespread distribution of nitric oxide (NO) synthases (NOS). Furthermore, in three human cell lines derived from hum...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2006-01, Vol.66 (2), p.770-774
Main Authors: QUINTERO, Marisol, BRENNAN, Peter A, THOMAS, Gareth J, MONCADA, Salvador
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Fundamental and applied biological sciences. Psychology
Medical sciences
Molecular and cellular biology
Otorhinolaryngology. Stomatology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Widespread expression of the α-subunit of hypoxia-inducible factor (HIF-1α) was observed in samples of human oral squamous cell carcinoma. In all the cases, this was accompanied by a widespread distribution of nitric oxide (NO) synthases (NOS). Furthermore, in three human cell lines derived from human oral squamous cell carcinoma, the accumulation of HIF-1α was prevented either by inhibition of NOS activity with the nonspecific NOS inhibitor NG-monomethyl-l-arginine or by the antioxidants N-acetyl-l-cysteine and ascorbic acid. We suggest that, in certain forms of cancer, NO might be responsible for the accumulation of HIF-1α by a mechanism dependent on free radicals. (Cancer Res 2006; 66(2): 770-4)
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-05-0333