Impaired fear memory and decreased hippocampal neurogenesis following olfactory bulbectomy in rats

It has been proposed that a decrease in adult hippocampal neurogenesis provides a biological and cellular basis for major depression. The olfactory bulbectomy (OB) in rats is widely accepted as an animal model of depression. In the present study, we investigated the effect of OB on memory formation...

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Published in:The European journal of neuroscience 2005-12, Vol.22 (11), p.2871-2878
Main Authors: Jaako-Movits, Külli, Zharkovsky, Alexander
Format: Article
Language:English
Subjects:
Animals
Antimetabolites
Avoidance Learning - physiology
Bromodeoxyuridine
Cell Count
Cell Death - physiology
Cell Differentiation - physiology
Cell Proliferation
Conditioning (Psychology) - physiology
Cytoplasmic Granules - physiology
Dentate Gyrus - cytology
Dentate Gyrus - physiology
Fear - physiology
Fear - psychology
fear conditioning
Hippocampus - cytology
Male
Memory - physiology
neurogenesis
Neurons - physiology
Olfactory Bulb - physiology
olfactory bulbectomy
Phenotype
Rats
Rats, Wistar
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Summary:It has been proposed that a decrease in adult hippocampal neurogenesis provides a biological and cellular basis for major depression. The olfactory bulbectomy (OB) in rats is widely accepted as an animal model of depression. In the present study, we investigated the effect of OB on memory formation in the memory tasks related to the hippocampal function and adult hippocampal neurogenesis. OB induced a behavioural syndrome, which was characterized by an increased activity in the open‐field test and impairment in passive avoidance behaviour and contextual fear conditioning. The behavioural changes, following OB, were accompanied by a decrease in the number of proliferating cells in the dentate gyrus. Furthermore, the differentiation of the newly born cells, into mature calbindin‐positive neurons, was also retarded. Stereological analysis revealed a decrease in the total granule neuron numbers within the granule cell layer of the dentate gyrus, without a significant decrease in volume of the dentate gyrus. Although a relationship between altered neurogenesis and behavioural syndrome, induced by OB, is not established yet, our results suggest that decreased neurogenesis might at least partly contribute for behavioural deficits following OB.
ISSN:0953-816X
1460-9568
DOI:10.1111/j.1460-9568.2005.04481.x