IGF-1 administration to prepubertal female rats can overcome delayed puberty caused by maternal Pb exposure

Because prepubertal female rats maternally exposed to lead (Pb) exhibit suppressed serum levels of insulin-like growth factor-1 (IGF-1) and delayed puberty, we investigated the ability of centrally administered IGF-1 to stimulate luteinizing hormone (LH) release in vivo and LH-releasing hormone (LHR...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2006, Vol.21 (1), p.104-109
Main Authors: Pine, Michelle D., Hiney, Jill K., Dearth, Robert K., Bratton, Gerald R., Dees, W. Les
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Delayed puberty
Embryology: invertebrates and vertebrates. Teratology
Female
Fisher 344 rats
Fundamental and applied biological sciences. Psychology
Gonadotropin-Releasing Hormone - metabolism
Gynecology. Andrology. Obstetrics
Insulin-Like Growth Factor I - pharmacology
Insulin-like growth factor-1
Lead (Pb) toxicity
Lead - blood
Lead - toxicity
Luteinizing hormone
Luteinizing Hormone - metabolism
Luteinizing hormone releasing hormone
Maternal-Fetal Exchange
Medical sciences
Metals and various inorganic compounds
Pregnancy
Prenatal Exposure Delayed Effects
Puberal and climacteric disorders (male and female)
Pubertal development
Puberty, Delayed - chemically induced
Puberty, Delayed - metabolism
Rats
Rats, Inbred F344
Teratology. Teratogens
Toxicology
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Summary:Because prepubertal female rats maternally exposed to lead (Pb) exhibit suppressed serum levels of insulin-like growth factor-1 (IGF-1) and delayed puberty, we investigated the ability of centrally administered IGF-1 to stimulate luteinizing hormone (LH) release in vivo and LH-releasing hormone (LHRH) release in vitro from maternally Pb-exposed prepubertal female rats. Additionally, we assessed whether IGF-1 replacement could affect the timing of female puberty. Results demonstrated that IGF-1 stimulated significantly LH release in both control and Pb-exposed animals. When median eminences from control and Pb-exposed females were incubated with rat IGF-1 in vitro, they responded similarly with significant peptide-induced LHRH release. Lastly, we showed IGF-1 replacement reversed the delay in puberty caused by Pb. These results indicate the central LHRH response to IGF-1 is intact and that Pb-induced delayed puberty is due, at least in part, to suppressed circulating IGF-1 available to the hypothalamus.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2005.07.003