Evaluation of two different biomarkers for use in the assessment of toxic chemical exposure in California sea lions ( Zalophus californianus)

Evaluation of two different biomarkers for use in the assessment of toxic chemical exposure in California sea lions is studied. The California sea lion trauma and cancer subgroups indicate that the type of health problem is not an appreciable factor for background rates of DNA damage or the treatmen...

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Bibliographic Details
Published in:Marine pollution bulletin 2006, Vol.52 (1), p.108-113
Main Authors: El-Zein, Randa A., Hastings-Smith, Darlene A., Ammenheuser, Marinel M., Treinen-Moslen, Mary, Gulland, Frances M., Ward, Jonathan B.
Format: Article
Language:English
Subjects:
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - toxicity
Animal, plant and microbial ecology
Animals
Apoptosis - drug effects
Applied ecology
Biological and medical sciences
Biomarkers - analysis
Cells, Cultured
Comet Assay - methods
Dose-Response Relationship, Drug
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
Environmental Exposure - analysis
Fundamental and applied biological sciences. Psychology
Humans
Hydrogen Peroxide - toxicity
In Situ Nick-End Labeling - methods
Lymphocytes - drug effects
Mammalia
Marine
Marine and brackish environment
Mutagens - toxicity
Neoplasms - pathology
Oxidants - toxicity
Pilot Projects
Sea Lions - blood
Wounds and Injuries - pathology
Zalophus californianus
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Summary:Evaluation of two different biomarkers for use in the assessment of toxic chemical exposure in California sea lions is studied. The California sea lion trauma and cancer subgroups indicate that the type of health problem is not an appreciable factor for background rates of DNA damage or the treatment-associated increase in DNA damage. Each treatment caused similar degrees of DNA damage in the sea lions compared to the humans. The Comet Assay super(TM) is a measure of the amount of DNA damage from single- or double-strand breaks, thus the observations suggest that lymphocytes from humans and from this population of sea lions have similar background levels of DNA damage. Some of the known environmental toxicants that California sea lions encounter have been reported to increase DNA strand breaks, as measured by the comet assay and expressed as an increase in tail extent moment (TEM).
ISSN:0025-326X
1879-3363
DOI:10.1016/j.marpolbul.2005.10.007