Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor

Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma was developed to evaluate the dynamics of endogenous AT II in various types of hypertension. Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT...

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Bibliographic Details
Published in:Immunopharmacology 1999-10, Vol.44 (1-2), p.199-204
Main Authors: Abe, Fumiaki, Omata, Ken, Yamada, Masaaki, Tsunoda, Kazuo, Sato, Tatsuyuki, Shimizu, Tetsu, Ito, Sadayoshi, Abe, Keishi, Nakazima, Megumi, Morimoto, Taeko, Takanashi, Naoki
Format: Article
Language:English
Subjects:
Analysis
Angiotensin converting enzyme (ACE) inhibitor
Angiotensin II
Angiotensin II - blood
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
captopril
dipeptidyl carboxypeptidase I inhibitors
Female
General pharmacology
Humans
Hyperaldosteronism - blood
Hyperaldosteronism - drug therapy
Hypertension
Hypertension - blood
Hypertension - drug therapy
Hypertension, Renal - blood
Hypertension, Renal - drug therapy
Medical sciences
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications, Cardiovascular - blood
Pregnancy Complications, Cardiovascular - drug therapy
Radioimmunoassay - methods
Renin
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Summary:Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma was developed to evaluate the dynamics of endogenous AT II in various types of hypertension. Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT I and III was 0.037% and 21%, respectively. There were good correlation between the value measured by direct method, and that of extraction method (r=0.96, P
ISSN:0162-3109
DOI:10.1016/S0162-3109(99)00090-9