INHIBITORY EFFECT OF MELATONIN ON PRODUCTS OF LIPID PEROXIDATION RESULTING FROM CHRONIC ETHANOL ADMINISTRATION

Despite decades of research, the role of free radicals in alcohol-induced organ injury is still a matter of debate. The present work was designed to investigate the potential protective effect of melatonin, a reported radical scavenger and antioxidant, on free radical toxicity induced by chronic eth...

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Bibliographic Details
Published in:Alcohol and alcoholism (Oxford) 1999-11, Vol.34 (6), p.842-850
Main Authors: El-Sokkary, Gamal H., Reiter, Russel J., Tan, Dun-Xian, Kim, Seok Joong, Cabrera, Javier
Format: Article
Language:English
Subjects:
Alcoholism - physiopathology
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Free Radicals
Lipid Peroxidation - drug effects
Male
Medical sciences
Melatonin - pharmacology
Membrane Lipids - metabolism
Rats
Rats, Sprague-Dawley
Tissue Distribution
Toxicology
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Summary:Despite decades of research, the role of free radicals in alcohol-induced organ injury is still a matter of debate. The present work was designed to investigate the potential protective effect of melatonin, a reported radical scavenger and antioxidant, on free radical toxicity induced by chronic ethanol administration. The major end-point of oxidative damage measured in this report was lipid peroxidation. Four groups of male Sprague–Dawley rats were used. The first group served as untreated controls and received a daily injection of alcoholic (
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/alcalc/34.6.842