Motor control in basal ganglia circuits using fMRI and brain atlas approaches

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2006-02, Vol.16 (2), p.149-161
• Main Authors: Lehéricy, Stéphane, Bardinet, Eric, Tremblay, Leon, Van de Moortele, Pierre-Francois, Pochon, Jean-Baptiste, Dormont, Didier, Kim, Dae-Shik, Yelnik, Jerome, Ugurbil, Kamil
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anatomy, Artistic; basal ganglia; Basal Ganglia - physiology; Brain Mapping - methods; Databases, Factual; Evoked Potentials, Motor - physiology; Feedback - physiology; Female; Fingers - physiology; globus pallidus; Humans; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Models, Anatomic; Motor Cortex - physiology; motor system; Movement - physiology; movement frequency; Muscle, Skeletal - innervation; Muscle, Skeletal - physiology; Nerve Net - physiology; Periodicity; Psychomotor Performance - physiology; subthalamic nucleus
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhi089

In this study, we examined how the motor, premotor and associative basal ganglia territories process movement parameters such as the complexity and the frequency of movement. Twelve right-handed volunteers were studied using EPI BOLD contrast (3 T) while performing audio-paced finger tapping tasks designed to differentiate basal ganglia territories. Tasks varied movement complexity (repetitive index tapping, simple sequence of finger movements and complex sequence of 10 moves) and frequency (from 0.5 to 3 Hz). Activation maps were coregistered onto a 3-D brain atlas derived from post-mortem brains. Three main patterns of activation were observed. In the posterior putamen and the sensorimotor cortex, signal increased with movement frequency but not with movement complexity. In premotor areas, the anterior putamen and the ventral posterolateral thalamus, signal increased regularly with increasing movement frequency and complexity. In rostral frontal areas, the caudate nucleus, the subthalamic nucleus and the ventral anterior/ventrolateral thalamus, signal increased mainly during the complex task and the high frequency task (3 Hz). These data show the different roles of motor, premotor and associative basal ganglia circuits in the processing of motor-related operations and suggest that activation can be precisely located within the entire circuitry of the basal ganglia.