Oligopeptides of Chorionic Gonadotropin β-Subunit in Induction of T Cell Differentiation into Treg and Th17

• Published in: Bulletin of experimental biology and medicine 2015-11, Vol.160 (1), p.72-75
• Main Authors: Zamorina, S. A., Shirshev, S. V.
• Format: Article
• Language: English
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; CD4-Positive T-Lymphocytes - drug effects; Cell Biology; Cell differentiation; Chorionic gonadotropin; Chorionic Gonadotropin, beta Subunit, Human - chemistry; Chorionic Gonadotropin, beta Subunit, Human - pharmacology; Drug Evaluation, Preclinical; Female; Humans; Interleukin-10 - biosynthesis; Interleukin-17 - biosynthesis; Interleukin-1beta - pharmacology; Interleukin-6 - pharmacology; Internal Medicine; Laboratory Medicine; Lymphopoiesis - drug effects; Microbiology and Immunology; Oligopeptides; Pathology; Peptide Fragments - pharmacology; T cells; T-Lymphocytes, Regulatory - cytology; T-Lymphocytes, Regulatory - metabolism; Th17 Cells - cytology; Th17 Cells - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-3101-8

The role of oligopeptides of chorionic gonadotropin β-subunit (LQGV, AQGV, and VLPALP) in induction of differentiation into T-regulatory lymphocytes (Treg) and IL-17-producing lymphocytes (Th17) was studied in an in vitro system. Chorionic gonadotropin and oligopeptides promoted CD4 + cell differentiation into functionally active Treg (FOXP3 + GITR + and FOXP3 + CTLA-4 + ), while chorionic gonadotropin and AQGV additionally stimulated IL-10 production by these cells. In parallel, chorionic gonadotropin and oligopeptides prevented CD4 + cell differentiation into Th17 lymphocytes (ROR-gt + IL-17A + ) and suppressed IL-17A secretion. Hence, oligopeptides of chorionic gonadotropin β-subunit promoted differentiation of CD4 + cells into Treg and, in parallel, suppress Th17 induction, thus virtually completely reproducing the effects of the hormone, which opens new vista for their use in clinical practice.