Circular RNA: A new star of noncoding RNAs

Highlights • CircRNAs are a stable and conserved class of RNA molecules, and exhibit tissue/developmental-stage-specific expression. • Reverse complementary sequences or RNA-binding proteins (RBPs) can promote the formation of circRNA. • CircRNAs can function as microRNA sponges and modifiers of par...

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Bibliographic Details
Published in:Cancer letters 2015-09, Vol.365 (2), p.141-148
Main Authors: Qu, Shibin, Yang, Xisheng, Li, Xiaolei, Wang, Jianlin, Gao, Yuan, Shang, Runze, Sun, Wei, Dou, Kefeng, Li, Haimin
Format: Article
Language:English
Subjects:
Alternative circularization
Biomarker
Biomarkers
Biosynthesis
Cancer
Circular RNA
Competition
Disease
Exoribonucleases - metabolism
Gene expression regulation
Gene Expression Regulation - genetics
Genes
Hematology, Oncology and Palliative Medicine
Humans
MicroRNA sponge
Neoplasms - genetics
Researchers
RNA - genetics
RNA polymerase
RNA Splicing - genetics
RNA, Untranslated - genetics
Transcription, Genetic - genetics
Tumor necrosis factor-TNF
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Summary:Highlights • CircRNAs are a stable and conserved class of RNA molecules, and exhibit tissue/developmental-stage-specific expression. • Reverse complementary sequences or RNA-binding proteins (RBPs) can promote the formation of circRNA. • CircRNAs can function as microRNA sponges and modifiers of parental gene expression. • CircRNAs play key roles in disease, especially in cancer, and serve as new diagnosis and treatment strategies for disease.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.06.003