Secretin receptor involvement in prion-infected cells and animals

•Secretin receptor signaling modifies prion formation in prion-infected cells.•Secretin receptor deficiency modifies disease progression in prion-infected mice.•Our findings may provide insight into gender specific-effects that occur in certain prion diseases. The cellular mechanisms behind prion bi...

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Bibliographic Details
Published in:FEBS letters 2015-07, Vol.589 (15), p.2011-2018
Main Authors: Kimura, Tomohiro, Nishizawa, Keiko, Oguma, Ayumi, Nishimura, Yuki, Sakasegawa, Yuji, Teruya, Kenta, Nishijima, Ichiko, Doh-ura, Katsumi
Format: Article
Language:English
Subjects:
abnormal isoform of prion protein
Animals
Base Sequence
Cell Line, Tumor
DNA Primers
Female
Gender effect
Gene Silencing
Incubation time
Knockout mouse
Male
Mice
N2a cells
normal cellular isoform of prion protein
Polymerase Chain Reaction
Prion
Prion Diseases - physiopathology
PrPc
PrPres
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - physiology
Receptors, Gastrointestinal Hormone - genetics
Receptors, Gastrointestinal Hormone - physiology
Sct
SctR
secretin
Secretin receptor
Sex Factors
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Summary:•Secretin receptor signaling modifies prion formation in prion-infected cells.•Secretin receptor deficiency modifies disease progression in prion-infected mice.•Our findings may provide insight into gender specific-effects that occur in certain prion diseases. The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells. Animal studies demonstrate that secretin receptor deficiency slightly, but significantly, prolongs incubation time in female but not male mice. This gender-specificity is consistent with our finding that prion-infected cells are derived from females. Therefore, our results provide initial insights into the reasons why age of disease onset in certain prion diseases is reported to occur slightly earlier in females than males.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2015.05.039