Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Highlights • Human stroke patients show reduced levels of interleukin-33 inhibitory receptor sST2. • Interleukin-33 administration is protective in a mouse model of cerebral stroke. • Interleukin-33 administration increased the brain and peripheral levels of interleukin-4. • Modulation of peripheral...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.322-336
Main Authors: Korhonen, Paula, Kanninen, Katja M, Lehtonen, Šárka, Lemarchant, Sighild, Puttonen, Katja A, Oksanen, Minna, Dhungana, Hiramani, Loppi, Sanna, Pollari, Eveliina, Wojciechowski, Sara, Kidin, Iurii, García-Berrocoso, Teresa, Giralt, Dolors, Montaner, Joan, Koistinaho, Jari, Malm, Tarja
Format: Article
Language:English
Subjects:
Aged
Allergy and Immunology
Animals
Astrocytes - metabolism
Brain - drug effects
Brain - immunology
Brain - metabolism
Brain Ischemia - blood
Brain Ischemia - immunology
Brain Ischemia - prevention & control
Cells, Cultured
Cerebral stroke
Cytokines
Cytokines - metabolism
Female
Humans
Inflammation
Inflammation - metabolism
Inflammation - prevention & control
Interleukin
Interleukin-33 - administration & dosage
Interleukin-33 - blood
Interleukin-4 - metabolism
Macrophages - drug effects
Macrophages - immunology
Male
Mice
Mice, Inbred BALB C
Microglia - drug effects
Microglia - immunology
Motor Activity - drug effects
Peripheral immune system
Psychiatry
Receptors, Somatostatin - blood
Recombinant Proteins - administration & dosage
Spleen - drug effects
Spleen - immunology
Spleen - metabolism
Stroke - blood
Stroke - immunology
Stroke - prevention & control
T-Lymphocytes - metabolism
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Summary:Highlights • Human stroke patients show reduced levels of interleukin-33 inhibitory receptor sST2. • Interleukin-33 administration is protective in a mouse model of cerebral stroke. • Interleukin-33 administration increased the brain and peripheral levels of interleukin-4. • Modulation of peripheral immunity impacts the outcome of stroke.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.06.013