Nucleotide modulates odor response through activation of purinergic receptor in olfactory sensory neuron

Extracellular nucleotides are important neurotransmitters, neuromodulators and paracrine factors in the neural sensory system [16]. Most of purines and pyrimidines act on the associated purinergic cell-surface receptors to mediate sensory transduction and modulation. Previously, we reported a subgro...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2015-08, Vol.463 (4), p.1006-1011
Main Author: Yu, Yiqun
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - physiology
Animals
Calcium - metabolism
Calcium imaging
Mice
Mice, Inbred C57BL
Nucleotide
Odorants
Olfactory sensory neuron
Purinergic Agonists - pharmacology
Purinergic receptor
Receptors, Purinergic - physiology
Sensory Receptor Cells - drug effects
Sensory Receptor Cells - metabolism
Sensory Receptor Cells - physiology
Uridine Triphosphate - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extracellular nucleotides are important neurotransmitters, neuromodulators and paracrine factors in the neural sensory system [16]. Most of purines and pyrimidines act on the associated purinergic cell-surface receptors to mediate sensory transduction and modulation. Previously, we reported a subgroup of heptaldehyde (H)/2-hepatanone (Ho)-responsive olfactory sensory neurons (H/Ho-OSNs) in the ventral endoturbinates [31]. Through the calcium image recording, we characterized that ATP elicited [Ca2+]i increase in the presence of extracellular calcium, while depletion of intracellular calcium stores blocked UTP-evoked [Ca2+]i increase. Pharmacological studies indicated that P2X3 was expressed in the H/Ho-OSNs, modulating both heptaldehyde (H) and 2-hepatanone (Ho)-induced responses. These data indicated that activation of purinergic receptor negatively modulated odor response, providing the evidence to support the possible protective effect of purinergic receptor in OSNs. •P2X3 receptor is expressed in a subgroup of olfactory sensory neurons, responsive to heptaldehyde (H) and 2-hepatanone (Ho).•P2X3 receptor negatively modulates both heptaldehyde (H) and 2-hepatanone (Ho)-induced responses.•This modulation potentially provides a protective function in OSNs.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2015.06.050